TABAQUISMO PARENTAL Y RIESGO DE LEUCEMIA LINFOBLÁSTICA AGUDA INFANTIL EN SOLCA GUAYAQUIL, ECUADOR
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Abstract
Acute lymphoblastic leukemia (ALL) is a malignant neoplasm related to blood, it has a high
incidence in Ecuador, but its origin remains not completely clarified. Previous studies have found
that cigarette smoke contains several chemicals that damage pluripotent hematopoietic stem cells
and myeloid cells, but their impact on the lymphoid lineage is unknown. Also considering the
scarcity of updated evidence, and its contradictory nature, it was necessary to design the present
case-control study with the objective of determining the influence of parental smoking on the
development of ALL. The 103 selected cases corresponded to a sample of children diagnosed with
ALL who attended with their biological parents for a control consultation at SOLCA-Guayaquil,
while the 103 controls were randomly selected from children without ALL treated at the outpatient
clinic of IESS Ceibos. Two sources were used to collect data: 1) the medical history and 2) a
smoking history questionnaire. To determine the association between parental smoking and
childhood ALL Fisher's exact test or Chi-Square was used, and the odds ratio was estimated by
means of multivariate logistic regression. Based on the findings of the logistic regression, its
concluded that paternal smoking before and during conception increases the risk of ALL (1.9 and
3.1 times, respectively). Furthermore, dependent maternal smoking also increases the risk of ALL
by 2.7 times if it occurs after birth. Therefore, the importance of avoiding maternal and paternal
smoking before, during and after conception should be promoted.